Metformin
Metabolic support for healthy aging
Metformin is a well-known oral medication traditionally used to manage type 2 diabetes. In recent years, it has gained recognition in longevity and anti-aging medicine due to its impact on insulin sensitivity, mitochondrial health, inflammation, and cellular aging. As a caloric restriction mimetic, Metformin is now widely used off-label to support metabolic health, fat loss, and cellular resilience, with potential to reduce age-related diseases and improve health span.
Metabolic support for healthy aging
What it can do
- Enhances insulin sensitivity
- May reduce visceral fat
- Supports mitochondrial function
- May reduce age-related diseases
- Activates AMPK/autophagy
What to watch for
- Nausea
- Diarrhea
- Gas
- Metallic taste
- B12 deficiency (annual check)
- Lactic acidosis (rare)
What to expect
Week 1-2: blood sugar/appetite control · Week 4+: energy, fat loss, clarity.
Questions about Metformin.
What can I expect with Metformin treatment?
• Start with 500mg once daily, gradually titrate up to 1000–2000mg daily if tolerated • Week 1–2: Improved blood sugar and appetite control • Week 4+: Enhanced energy, fat loss, cognitive clarity • Full anti-aging and metabolic benefits seen with consistent, long-term use • Typically used alongside nutrition and exercise guidance from your physician • Missed dose? Skip and resume at the next scheduled time; do not double up
What are the possible side effects of Metformin?
Common (Typically transient): Nausea, Diarrhea, Gas or bloating, Metallic taste Less Common / Monitor If Present: Vitamin B12 deficiency (check annually), Lactic acidosis (rare; risk higher in kidney/liver impairment or alcohol abuse), Decreased appetite or mild fatigue Precautions: Not recommended in patients with eGFR <30 mL/min. Caution with alcohol or severe calorie restriction. Monitor B12 annually with long-term use. Take with food to reduce GI side effects.
